Breida isn't practicing Wednesday due to knee and calf injuries, Matt Maiocco of NBC Sports Bay Area reports.
Breida was diagnosed with a hyperextended knee after Sunday's 38-27 loss to Kansas City, piling up 117 scrimmage yards despite missing some time during the first half. It wasn't known that he was also battling the calf injury, but there's no reason to believe either issue is serious. Jimmy Garoppolo's season-ending knee injury is probably the bigger concern for Breida's fantasy value, as the 49ers likely will have trouble scoring points with C.J. Beathard under center. Alfred Morris (ankle) and Raheem Mostert would stand to benefit if Breida isn't available for Sunday's game against the Chargers.