Wilson and JaMycal Hasty will be the 49ers' primary running backs Sunday at Cincinnati with both Elijah Mitchell (concussion/knee) and Trenton Cannon (concussion) ruled out for the contest, Matt Maiocco of NBC Sports Bay Area reports.
The opportunity is there for Wilson to make an impact out of San Francisco's backfield, but he's coming off a game in which he lasted just one play on offense and 11 on special teams last Sunday at Seattle when he dinged up his surgically repaired knee. Since making his season debut Week 10, he's averaged 2.7 yards on his 31 carries and recorded two catches (on three targets) for 10 yards in four games. Considering Hasty has been more of a pass-catching threat this season -- he has 13 rushes and caught 13 of 18 targets -- Wilson may earn more of the early down and short-yardage work of the two players.