Coach Kyle Shanahan said Wednesday that Wilson (ankle) is considered day-to-day, Chris Biderman of The Sacramento Bee reports.
Wilson suffered a sprained ankle in Week 7 against the Patriots and sat out three games as a result. The 25-year-old running back was designated to return from injured reserve Tuesday, opening a 21-day window for him to rejoin the roster. Depending on how his ankle responds to a week of practice, Wilson could play in this Sunday's game against the Rams. His role depends on the health of the other backs, as Tevin Coleman (knee), Jerick McKinnon (neck) and Raheem Mostert (knee) are all banged up to varying degrees.