The 49ers designated Wilson (ankle) to return from injured reserve Tuesday, Cam Inman of The San Jose Mercury News reports.
San Francisco has 21 days to evaluate Wilson for a return to the 53-man roster. Before being moved to IR due to a sprained ankle, Wilson turned in his best game as a pro in the 49ers' Week 7 win over New England, rumbling 17 times for 112 yards and three scores while catching two passes for eight yards. Even if he proves healthy in practice, Wilson may have a tough time reclaiming a consistent role in the backfield, as top option Raheem Mostert (ankle) was also designated to return from IR on Tuesday and may be ready to play as soon as Sunday against the Rams. In addition to Mostert, Tevin Coleman (knee) and Jerick McKinnon (neck) are also likely ahead of Wilson on the depth chart.