Jennings turned three receptions (six targets) into 88 yards in Sunday's 30-13 victory over New England.
Jennings failed to replicate last week's three-score performance for eager fantasy managers, but the veteran receiver still led the 49ers in targets and receiving yards, and that was with fellow starters Deebo Samuel (calf) and Brandon Aiyuk both active. San Francisco's slot man remains a hot play in fantasy while his role on offense remains enlarged sans Christian McCaffrey (calf/Achilles). The case can be made for Jennings to start in nearly any format, given his recent production and a favorable home matchup against Arizona on tap for Week 5.