Mitchell is dealing with a rib injury and is expected to be limited in practice Wednesday, Nick Wagoner of ESPN.com reports.
Mitchell ran roughshod over the Bears on Sunday, turning 18 carries into 137 yards and one touchdown. It marked his third 100-yard game in five appearances as a pro, but he's also now poised to appear on the 49ers' injury report for the second time this season. With practice limitations set to be placed on Mitchell, the team's healthy running backs are JaMycal Hasty, Trey Sermon and Trenton Cannon, while Jeff Wilson's (knee) practice window to return from the PUP list may open this week and Raheem Mostert (knee) is out for the season.