Mitchell (knee) rushed 21 times for 119 yards and caught both of his targets for 11 yards and a touchdown in Sunday's 23-7 win over Houston.
Mitchell returned from a three-game absence and did not skip a beat, producing his sixth 100-plus yard rushing game while collecting his sixth total touchdown of the season in the process. The talented rookie didn't show any residual effects from the knee or head injuries he recovered from, re-establishing himself as the 49ers' clear top back. Mitchell's fantasy managers should also be pleased with the heavy workload despite having a different style of quarterback under center. San Francisco's quarterback situation is unclear heading into the final week of the regular season, but Mitchell should remain a strong fantasy play no matter who starts under center against the Rams.