Mitchell (concussion/knee) isn't practicing Friday and thus appears unlikely to play in Sunday's game against the Falcons, Matt Maiocco of NBC Sports Bay Area reports.
Mitchell did some work with the training staff Wednesday and Thursday but ultimately missed every practice for a second straight week. If he does end up sitting again, Jeff Wilson would figure to lead the San Francisco backfield, albeit in a smaller role than what Mitchell's handled for most of the year, with WR Deebo Samuel taking some of the carries while JaMycal Hasty and Kyle Juzsczyk play a bunch of pass snaps.