Mitchell (knee) will be a limited practice participant Wednesday, Eric Branch of the San Francisco Chronicle reports.
Mitchell sustained a concussion Week 13 at Seattle, and while recovering from the head injury it was discovered that he was dealing with knee irritation. He cleared the concussion protocol last Monday, but the latter issue kept him sidelined for a third consecutive contest last Thursday in Tennessee. Mitchell's appearance on the practice field Wednesday will mark his first since picking up the initial health concern, which may pave the way for him to return to action this Sunday against the Texans.