Mitchell (knee), who is listed as questionable for Sunday's game against Houston, is expected to play, Adam Schefter of ESPN reports.
Mitchell, who hasn't played since Week 13, returned to practice Wednesday as a limited participant. He maintained that level of activity Thursday and Friday, giving the 49ers enough confidence in his health heading into the penultimate game of the regular season. Fantasy managers will still want to confirm Mitchell is good to go when the 49ers release their inactive list 90 minutes prior to the game's 4:05 p.m. ET kickoff, but if cleared, he'll presumably step back into a lead role out of the San Francisco backfield.