Mitchell (finger) is listed as doubtful for Sunday's game in Jacksonville, Matt Maiocco of NBC Sports Bay Area reports.
It's been a roller-coaster week in terms of Mitchell's outlook, with early pessimism replaced by optimism Wednesday afternoon when coach Kyle Shanahan said he expected the running back to play. That was one day after Mitchell had surgery on his broken finger, and since then he's been held out of practice and limited to side work with the training staff. Fellow running back JaMycal Hasty (ankle) is also ruled out for Sunday's game, leaving Jeff Wilson, Trey Sermon, Trenton Cannon and FB Kyle Juszczyk as the backfield options. Cam Inman of The San Jose Mercury News and David Lombardi of The Athletic both expect Wilson to get the start and presumably most of the carries, while Juszczyk has often handled third-down work when Hasty's been unavailable this year.