Mitchell (shoulder) returned to Sunday's contest in Philadelphia, Nick Wagoner of ESPN.com reports.
The 49ers may not have pressed their luck with Mitchell after he was diagnosed with a shoulder injury and deemed questionable to return, but fellow rookie Trey Sermon took a hit to the helmet on his first career carry (which was nullified by an Eagles penalty) and laid on the field for a spell before going to the sideline and eventually the locker room. It appears as if San Francisco will rely on Mitchell and JaMycal Hasty for the remainder of Week 2.