Coach Kyle Shanahan said Monday that Samuel suffered a calf strain and is slated to miss "a couple weeks," David Lombardi of The Athletic reports.
Samuel presumably picked up the health concern during Sunday's loss to the Vikings, a contest in which he logged a typical snap share (86 percent) while recording eight catches (on 10 targets) for 110 yards and two carries for minus-2 yards. With Samuel in line to miss game action, Jauan Jennings likely will be the primary beneficiary next to starting WR Brandon Aiyuk, but Chris Conley, Ronnie Bell and Jacob Cowing are the other options at the position on the active roster.