Head coach Kyle Shanahan said Samuel (calf) won't practice Wednesday, Matt Barrows of The Athletic reports.
Samuel's absence to begin Week 3 prep comes as no surprise after Shanahan relayed Monday that the wideout was slated to miss "a couple" games due to the strained right calf that he suffered late in this past Sunday's loss at Minnesota, per Matt Barrows of The Athletic. Samuel thus is destined to be ruled out by week's end ahead of Sunday's road matchup with the Rams. Jauan Jennings is poised to jump into the starting lineup alongside Brandon Aiyuk during Samuel's absence, while Chris Conley, Ronnie Bell and Jacob Cowing are the other healthy wide receivers in the 49ers' active roster.