Samuel (calf) has been ruled out for Sunday's game against the Rams, Matt Barrows of The Athletic reports.
Samuel didn't practice at all this week and is expected to miss multiple games after injuring his calf in the fourth quarter of a Week 2 loss to Minnesota. With RB Christian McCaffrey (Achilles) on injured reserve and George Kittle (hamstring) listed as doubtful, the 49ers are suddenly thin on skill-position talent, leaving RB Jordan Mason and WRs Brandon Aiyuk and Jauan Jennings as the favorites to pile up yards this Sunday in Los Angeles. Reports this week didn't sound promising for Samuel's chances to return next Sunday against the Patriots (Sept. 29).