Aiyuk had five receptions on 10 targets for 48 yards in Sunday's 27-24 loss to the Rams.
Aiyuk failed to deliver in a prime opportunity to prove his new worth, with the 49ers lacking Christian McCaffrey (calf/Achilles), George Kittle (hamstring) and Deebo Samuel (calf). The wideout provided middling results on 10 targets, notably dropping a pass from Brock Purdy that hit the receiver in the mitts. Aiyuk will look to post big numbers against the Patriots next week after recording a disappointing 11/119/0 receiving line through three contests.