Grisham was removed from Wednesday's game against the Blue Jays with left knee discomfort.
Grisham wasn't moving well after legging out a double in the second inning, and the Yankees eventually decided to take him out of the game in the fifth. The team will send him in for imaging Thursday, at which point more will be known regarding his status. Should he have to miss time, Spencer Jones would be the favorite to pick up starts in center field.