Plouffe was scratched from Sunday's lineup against the Rangers due to sore ribs, LaVelle Neal of the Minneapolis Star Tribune reports.
Manager Paul Molitor was looking to give regular first baseman Joe Mauer a day off with lefty Cole Hamels starting for the Rangers, but those plans were thrown out the window when Plouffe acknowledged the injury shortly before first pitch. The Twins will likely take a day-to-day view with Plouffe's injury, making it uncertain if he'll be able to return to action in Monday's series opener with the Athletics.