Plouffe went 1-for-3 with a sacrifice fly, solo homer and a walk in Friday's 15-8 loss to the Blue Jays.
The veteran slugger opened the scoring with a 409-foot solo shot in the first, before adding a third-inning sacrifice fly that brought home Kurt Suzuki. The round-tripper was Plouffe's first since July 1, the game before he went on an extended DL stint with a rib injury.