Jeffers went 1-for-4 with a solo home run in Tuesday's 5-2 loss to the Guardians.
The backstop took Parker Messick deep in the top of the first inning for his ninth long ball of the season, but it was the only lead the Twins would hold in the game. Jeffers missed nearly two months after undergoing surgery on a fractured hamate bone in May, but he hasn't shown much rust since returning just before the All-Star break, going 5-for-21 (.238) in six games with two doubles and two homers.