Lewis isn't in the lineup for Saturday's game against the Cubs due to left hamstring soreness, Dan Hayes of The Athletic reports.
Manager Derek Shelton said Lewis has already begun to feel better since reporting to the ballpark Saturday, but the Twins will keep him on the bench as a precaution. His absence will put Josh Bell at first base, moving Ryan Jeffers to the DH spot and giving Victor Caratini a start at catcher.