Holton will serve as the Tigers' opening pitcher for Game 2 of Thursday's doubleheader against the Pirates, Cody Stavenhagen of The Athletic reports.
Keider Montero is likely to absorb the bulk of the innings out of the bullpen. It will be the fourth opener assignment this season for Holton, who has allowed two runs with a 5:0 K:BB over four innings in his first three tries.