Ryan (hamstring) will start Wednesday at Triple-A Toledo, Chris McCosky of The Detroit News reports.
It will be Ryan's organizational debut after he was acquired from the Dodgers in the Tarik Skubal trade last month. The 28-year-old has made just eight starts this season, registering a 4.46 ERA, 1.29 WHIP and 43:8 K:BB across 36.1 innings with Triple-A Oklahoma City prior to being dealt to the Tigers. Ryan figures to be a member of Detroit's rotation next season but could debut with the big club later this month.