The Tigers placed Keith on the 10-day injured list Monday due to a left thumb sprain.
He missed a couple games last week with thumb soreness, and subsequent testing revealed a sprain. The injury will bring an end to the season for Keith, who finishes with a .258/.322/.406 batting line and 10 home runs over 140 contests for the Tigers. Gleyber Torres and/or Eduardo Valencia could handle designated-hitter duties for the Tigers in the final week while Keith is out.