Manager Mike Matheny announced Wednesday that Greinke will start Opening Day against the Guardians on April 7, Josh Vernier of 610 Sports Kansas City reports.
The veteran right-hander inked a one-year, $13 million deal with Kansas City in mid-March, and the start on Opening Day will be his first time taking the mound for the organization since 2010. Greinke had a 4.16 ERA, 1.17 WHIP and 120:36 K:BB over 171 innings with the Astros last season.