The Royals activated Ragans (shoulder) from the 60-day injured list Wednesday.
After being sidelined for more than three months with a left rotator cuff strain, Ragans will make his return to the Royals rotation Wednesday against the Mariners at Kauffman Stadium. Ragans made two rehab starts with Triple-A Omaha prior to being activated, allowing just one run with a 14:2 K:BB over 6.2 innings. The left-hander threw 56 pitches in his most recent rehab outing this past Friday, so his workload will be relatively limited versus the Mariners.