Mondesi was removed from Tuesday's game against the White Sox with left knee discomfort, Alec Lewis of The Athletic reports.
The 26-year-old suffered the injury during the sixth inning while returning to first base on a pickoff attempt, and he was promptly lifted for a pinch runner. Mondesi continues to be evaluated, but manager Mike Matheny said the initial scans of the injury are encouraging, according to Anne Rogers of MLB.com.