De La Cruz went 1-for-4 with two walks and a run scored in Wednesday's 6-5 loss to the Brewers.
This was De La Cruz's second game back off the injured list, where he spent three weeks with a hamstring injury. He's 1-for-7 with two walks in the two games back. De La Cruz's return comes at a pivotal time for the Reds, who have lost 14 of the last 21 games and now sit 12.5 games out of first place and 5.5 out of an NL Wild Card spot.