Yoshida left Saturday's game against the Pirates in the top of the third inning after sliding into second base on a double, Gabrielle Starr of the Boston Herald reports.
The 33-year-old slid head-first into second base after legging out a double and came up limping before being removed from the game. Officially, he exited with left hamstring tightness, per Ian Browne of MLB.com. Anthony Seigler pinch ran for Yoshida and will remain in the game as Boston's designated hitter.