Santana (ankle) was activated from the 15-day injured list Tuesday.
Santana has been on the shelf with the ankle sprain for the past three weeks, and he'll rejoin the Rangers on Tuesday after a two-game rehab assignment with Triple-A Round Rock. The 26-year-old was a reliable high-leverage arm for Texas over the first three months of the season with one save, 12 holds and a 1.53 ERA, but he posted 15.43 ERA in July before landing IL in early August.