Cruz is out of the lineup for Wednesday's game against the Padres.
After making a return from an illness, Cruz had started in each of the Pirates' last six games, going 9-for-24 with three extra-base hits and a 3:6 BB:K. Though he looks to be fully healthy again, Cruz will join fellow left-handed hitters Rowdy Tellez and Ji Hwan Bae on the bench as the Padres send southpaw Martin Perez to the hill.