Keller (1-2) was charged with the loss against the Padres on Thursday after surrendering seven runs on nine hits and three walks. He struck out one over 3.1 innings.
Most of Keller's damage came from a four-run first inning during which the Padres hit him hard, including an RBI double by Jake Cronenworth and a two-run home run by Manny Machado. Keller, who has struggled with command in what's been an up-and-down April, issued three walks and now has an uninspiring 12:8 K:BB across 11.1 innings. The right-hander will look to improve upon a disappointing 8.74 ERA and 2.12 WHIP when the Pirates head to Detroit on Wednesday.