The Padres activated Ramirez (shoulder) from the 10-day injured list Monday and optioned him to Triple-A El Paso.
The transaction clears a spot on the active roster for infielder Adam Frazier, whom the team officially acquired Monday in a trade with the Pirates. Ramirez was placed on the IL on July 8 with left rotator cuff inflammation, but he was cleared to begin a rehab assignment at El Paso last week and appears to be fully healthy.