Lucchesi was added to the Padres' active roster prior to his major-league debut against Milwaukee on Friday.
In a corresponding move, catcher Raffy Lopez was optioned to Triple-A El Paso. Over 60.1 innings of work at the Double-A level last season, Lucchesi posted a 1.79 ERA and 1.00 WHIP with a 53:14 K:BB.