Akin was placed on the COVID-19 injured list on Wednesday.
The 26-year-old was slated to serve as the starting pitcher in Wednesday's series finale against the Rays, but left-hander Alexander Wells will take his place after he was recalled as part of a corresponding move. The Orioles haven't disclosed whether Akin tested positive for the virus, so he may only end up missing one turn through the rotation if he's able to quickly clear health and safety protocols.