Lyles (0-1) took the loss after he pitched five innings, allowing five runs on seven hits and three walks while striking out two in Saturday's defeat against the Rays.
The 31-year-old pitched a clean first inning, but struggled over the next two frames, surrendering all five runs over that span. Lyles struggled to keep the Rays off the basepaths, allowing 10 batters to reach base. Coming off a 2021 campaign in which he compiled a 5.15 ERA and 1.39 WHIP while starting 30 games with the Rangers, the left-hander failed to start off the 2022 season on the right foot. He is projected to be back on the mound Wednesday at home versus the Brewers.