Lyles (3-5) took the loss against Kansas City on Thursday, allowing six runs on eight hits and three walks while striking out one over five innings.
Lyles got through two scoreless innings to start the contest before the Royals put up four runs in the third. The right-hander bounced back with a scoreless fourth frame but served up a Carlos Santana two-run homer in the fifth. Lyles tied a season-worst mark by giving up six earned runs in the outing, pushing his ERA to 4.97 on the campaign. He's struck out only seven batters over his past 14.1 innings, further weakening his case for a spot on fantasy squads.