Lyles is starting the first game of Saturday's doubleheader against the Red Sox, Zachary Silver of MLB.com reports.
Lyles has posted a 3.31 ERA and 1.19 WHIP in 32.2 innings over five starts in May, and he'll make his 10th start of the season during Saturday's matinee. Although he posted a quality start in four of his last five outings, the right-hander was limited to two wins during that time.