The Orioles designated Reyes for assignment Wednesday, Zachary Silver of MLB.com reports.
He'll lose out on a 40-man spot with the Orioles selecting the contract of top prospect Gunnar Henderson ahead of Wednesday's game against the Guardians. Reyes, who hasn't surfaced in the big leagues since being optioned to the minors June 5, owns a 7.50 ERA and 1.60 WHIP across 42 innings at Triple-A Norfolk this season.