The Mariners placed Canzone on the 10-day injured list Wednesday with a right adductor strain.
Canzone initially suffered the injury during Sunday's 5-4 loss to the Blue Jays while making a catch and then aggravated it while running in Tuesday's 8-3 win. He'll be eligible to return from the IL shortly after the All-Star break, but it's uncertain whether Canzone will be ready for activation at that time.