Canzone (hamstring) will start at designated hitter and bat sixth Wednesday against the Pirates.
He'll check back into the starting nine after a right hamstring injury kept him from playing in Tuesday's 3-2 win. The 29-year-old has been holding down a strong-side platoon role at DH for the Mariners this season and has torched right-handed pitching to the tune of a .288/.348/.581 slash line with 11 home runs in 178 plate appearances.