Santana is out of the lineup for Sunday's game against the White Sox.
Jose Ramirez is getting a partial day off as the designated hitter, leaving no room in the starting nine for Santana. The switch-hitting Santana should still be locked into an everyday role against left-handed pitching, but he could have to settle for a part-time role versus righties if the Guardians remain committed to opening up playing time for younger bats.