Civale was placed on the 15-day injured list with a right wrist sprain Thursday, Tom Withers of the Associated Press reports.
Civale exited Wednesday's start against the White Sox due to the wrist injury, and he'll be sidelined until at least late July after receiving his diagnosis. The Guardians won't need to fill his place in the rotation until after the All-Star break, but it's not yet clear when the 27-year-old is expected to return to game action.