Melancon (0-3) gave up one run on one hit -- a walkoff home run -- over two-thirds of an inning to take the loss to the Cardinals on Saturday.
Melancon was called upon in a tie game in the 10th inning and recorded two outs before Tyler O'Neill won the game with a solo shot. The 33-year-old had a run of nine appearances with just one earned run, but he's given up three runs in his last two outings.