Santana will start Thursday's game against the Pirates, Ken Gurnick of MLB.com reports.
Santana made his big-league debut in a shaky long-relief appearance Saturday at Coors Field, where he allowed five runs on six hits over 3.2 innings. The Dodgers were undeterred by the rocky showing, as they'll pencil him in for his first career start Thursday in Pittsburgh. If he performs well, Santana could enjoy an extended stay in the rotation due to the myriad of injuries to the other Dodgers starters.