Wetherholt went 1-for-4 with a two-run home run in Thursday's 9-7 win over the Rays.
The top prospect made an immediate splash in his major-league debut, taking Rays right-hander Drew Rasmussen deep in the third inning. After making St. Louis' Opening Day roster this spring, Wetherholt is set up in a favorable lineup spot right away after batting leadoff Thursday, which should aid his run-scoring potential.