Guerrero was removed from Tuesday's game against the Nationals due to right hamstring tightness, Keegan Matheson of MLB.com reports.
The severity of Guerrero's injury is unclear, but the Blue Jays may provide an update on his status after the game. With Lenyn Sosa (wrist) on the injured list, Kazuma Okamoto would likely cover first base if Guerrero were to miss any games, clearing the way for Luis Urias to start in the infield.