The Astros placed Loperfido on the 10-day injured list Sunday due to a right quadriceps strain.
The 26-year-old sustained the quad injury during Friday's 9-4 loss to the Cardinals. Loperfido will be eligible to be reinstated April 28, and Astros general manager Dana Brown said during a radio appearance Sunday that he's optimistic that the 26-year-old outfielder will be ready to return at that time, per Brian McTaggart of MLB.com. In the meantime, the Astros will likely lean on Brice Matthews, Dustin Harris and Shay Whitcomb to pick up reps in left field in Loperfido's absence.