Pena was removed from Tuesday's game against the Mariners after getting hit on the wrist by a pitch, Chandler Rome of The Athletic reports.
Pena ran the bases for himself after taking a 96.4-mph sinker off his right wrist in the eighth inning, but he was replaced at shortstop when the Astros' defense took the field in the bottom of the frame. He'll likely undergo X-rays to determine whether he suffered a fracture, and more information on his health may be available after the game.