Sousa (elbow) will throw a simulated game at Daikin Park on Wednesday, Brian McTaggart of MLB.com reports.
Sousa has been limited to only five appearances for the Astros this season, first missing time due to an oblique strain and more recently battling left elbow inflammation. He's been shelved for nearly two months but appears close to throwing in a game. Sousa appears unlikely to join the Astros' active roster before the All-Star break.